Effects of ischemic preconditioning on regenerative capacity of hepatocyte in the ischemically damaged rat livers

Bedirli A., Kerem M., Pasaoglu H., ERDEM O. A., Ofluoglu E., Sakrak O.

JOURNAL OF SURGICAL RESEARCH, cilt.125, sa.1, ss.42-48, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 125 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jss.2004.11.028
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.42-48
  • Anahtar Kelimeler: liver, ischemia-reperfusion, hepatectomy, regeneration, ischemic preconditioning, tumor necrosis factor-alpha, interleukin-6, REPERFUSION INJURY, INTERLEUKIN-6 PROTECTS, HEPATIC REGENERATION, MICE, CYTOKINES, ISCHEMIA/REPERFUSION, TRANSPLANTATION, APOPTOSIS, PROTEINS, ADHESION
  • Gazi Üniversitesi Adresli: Evet

Özet

Background. Liver regeneration after partial hepatectomy is regulated by several factors that activate or inhibit hepatocyte proliferation. A short period of ischemia-reperfusion (IR), called ischemic preconditioning (IPC), protects the liver against subsequent sustained ischemic insults. The present study investigated the effects of IPC on liver regeneration after partial hepatectomy under IR in rats.