Risk of Alzheimer's disease and environmental bisphenol A exposure

ENGİN A. B., ENGİN A.

CURRENT OPINION IN TOXICOLOGY, cilt.25, ss.36-41, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.cotox.2021.03.003
  • Dergi Adı: CURRENT OPINION IN TOXICOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.36-41
  • Gazi Üniversitesi Adresli: Evet

Özet

Environmental bisphenol A (BPA) exposure and bioaccumulation are higher than expected levels. In the long run, continuing BPA exposure impairs synaptic transmission and contributes to BPA-induced cognitive impairment, while increasing type 2 diabetes risk via promoting pancreatic b-cell death. BPA-insulin-Alzheimer's disease (AD) axis represents a neuro-endocrine disorder and is termed as "Type 3 Diabetes". BPA elevates oxidative stress and amyloid-beta accumulation in the AD brain, while increasing neuroinflammation and tauphosphorylation. Neuronal viability is protected at high glucose concentration and insulin resistance conditions by N-methyl-Daspartate (NMDA) receptor antagonists. Interestingly, despite its NMDA receptor suppressive effect, BPA contributes to neurotoxicity. Conversely, improvement of NMDA receptor functions shows protective effects against BPA-induced neurotoxicity. Thus, the mechanism of BPA neurotoxicity remains to be clarified.