Effects of antiepileptic drugs on dynamic thiol/disulphide homeostasis in children with idiopathic epilepsy

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ARHAN E., Kurt A. N. C., NEŞELİOĞLU S., Yerel O., Ucar H. K., Aydin K., ...Daha Fazla

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, cilt.65, ss.89-93, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.seizure.2018.12.019
  • Dergi Adı: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.89-93
  • Anahtar Kelimeler: Epilepsy, Dynamic thiol/disulphide homeostasis, Valproic acid, Carbamazepine, OXIDATIVE STRESS, LIPID-PEROXIDATION, VALPROIC ACID, SUPEROXIDE-DISMUTASE, TRACE-ELEMENTS, ANTIOXIDANT, GLUTATHIONE, CARBAMAZEPINE, EPILEPTOGENESIS, SYSTEMS
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose: Anti-epileptic drugs have been widely used in children with epilepsy. Although several studies have investigated the role of oxidative stress and the effects of antiepileptic drugs on several oxidative markers in epilepsy, adequate information is not available on this issue. This study aimed to investigate the changes in thiol disulphide homeostasis in children with epilepsy under two commonly prescribed AED monotherapies, carbamazepine and valproic acid.