Effects of antiepileptic drugs on dynamic thiol/disulphide homeostasis in children with idiopathic epilepsy


Creative Commons License

ARHAN E., Kurt A. N. C. , NEŞELİOĞLU S., Yerel O., Ucar H. K. , Aydin K., ...More

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, vol.65, pp.89-93, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 2019
  • Doi Number: 10.1016/j.seizure.2018.12.019
  • Journal Name: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.89-93
  • Keywords: Epilepsy, Dynamic thiol/disulphide homeostasis, Valproic acid, Carbamazepine, OXIDATIVE STRESS, LIPID-PEROXIDATION, VALPROIC ACID, SUPEROXIDE-DISMUTASE, TRACE-ELEMENTS, ANTIOXIDANT, GLUTATHIONE, CARBAMAZEPINE, EPILEPTOGENESIS, SYSTEMS

Abstract

Purpose: Anti-epileptic drugs have been widely used in children with epilepsy. Although several studies have investigated the role of oxidative stress and the effects of antiepileptic drugs on several oxidative markers in epilepsy, adequate information is not available on this issue. This study aimed to investigate the changes in thiol disulphide homeostasis in children with epilepsy under two commonly prescribed AED monotherapies, carbamazepine and valproic acid.