Mesoporous aluminosilicate HMS was synthesized and adopted as a support for Ni and Mo-containing catalysts. Characterization of various samples was performed through XRD and DRIFT techniques. Textural and morphological characteristics were examined using nitrogen adsorption/desorption isotherms. The presence of a mesoporous and ordered structure in the aluminosilicate and catalysts based on it is confirmed by the data of low-temperature adsorption/desorption of nitrogen and X-ray diffraction. A correlation was established between the structural, acidic and catalytic properties of HMS-based catalyst samples. The catalytic activity of Ni/HMS-H-bentonite and Mo/HMS-H-bentonite was investigated during the conversion of n-hexadecane. It was shown that the sample of molybdenum-promoted HMS-based catalyst possesses the highest activity and selectivity in the process of hydroisomerization of n-hexadecane under optimal conditions (320 degrees C, 1 h(-1)). The yield of isoparaffins on this sample is 42 wt% with a selectivity of 91%. (C) 2020 Elsevier Ltd. All rights reserved.