Protective effect of stobadine on NCV in streptozotocin-diabetic rats: augmentation by vitamin E


Skalska S., Kyselova Z., Gajdosikova A., Karasu C., Stefek M., Stolc S.

GENERAL PHYSIOLOGY AND BIOPHYSICS, cilt.27, sa.2, ss.106-114, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 27 Konu: 2
  • Basım Tarihi: 2008
  • Dergi Adı: GENERAL PHYSIOLOGY AND BIOPHYSICS
  • Sayfa Sayıları: ss.106-114

Özet

Hyperglycaemia-induced oxidative stress makes an important contribution to the aetiology of diabetic neuropathy. Elevated reactive oxygen species (ROS) cause cumulative damage to neurons and Schwan cells, however, they also have a deleterious effect on nerve blood flow causing endoneurial hypoxia, which is responsible for early nerve conduction velocity (NCV) deficits and contributes to an increase in resistance to ischaemic conduction failure (RICF).