Protective effect of stobadine on NCV in streptozotocin-diabetic rats: augmentation by vitamin E

Skalska S., Kyselova Z., Gajdosikova A., Karasu C., Stefek M., Stolc S.

GENERAL PHYSIOLOGY AND BIOPHYSICS, cilt.27, sa.2, ss.106-114, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2008
  • Dergi Adı: GENERAL PHYSIOLOGY AND BIOPHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.106-114
  • Anahtar Kelimeler: diabetes, neuropathy, oxidative stress, stobadine, rats, PYRIDOINDOLE ANTIOXIDANT STOBADINE, NERVE-CONDUCTION-VELOCITY, POLYOL PATHWAY METABOLITES, OXIDATIVE STRESS, PERIPHERAL-NERVE, DIETARY SUPPLEMENTATION, NEUROVASCULAR FUNCTION, VASCULAR DYSFUNCTION, LIPID-PEROXIDATION, REPERFUSION INJURY
  • Gazi Üniversitesi Adresli: Evet

Özet

Hyperglycaemia-induced oxidative stress makes an important contribution to the aetiology of diabetic neuropathy. Elevated reactive oxygen species (ROS) cause cumulative damage to neurons and Schwan cells, however, they also have a deleterious effect on nerve blood flow causing endoneurial hypoxia, which is responsible for early nerve conduction velocity (NCV) deficits and contributes to an increase in resistance to ischaemic conduction failure (RICF).