Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors

Kılıç, BURCU; Erdogan, Merve; Gulcan, Hayrettin; Aksakarl, Fatma; Oruklu, NİHAN; Bağrıaçık, EMİN; Doğruer, DENİZ

doi:10.2174/1573406414666180524073241

Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors

Kılıç B., Erdogan M., Gulcan H. O., Aksakarl F., Oruklu N., Bağrıaçık E. Ü., ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.15, sa.1, ss.59-76, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 1
Basım Tarihi: 2019
Doi Numarası: 10.2174/1573406414666180524073241
Dergi Adı: MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.59-76
Anahtar Kelimeler: Alzheimer's disease, pyridazinone, acetylcholinesterase inhibitory activity, butyrylcholinesterase inhibitory activity, molecular docking, rational drug design, 1(2H)-PHTHALAZINONE DERIVATIVES, E2020 ARICEPT(R), ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, TOXICITY, BINDING, AGENTS, SITE
Gazi Üniversitesi Adresli: Evet

Özet

Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.