Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors

Kılıç B. , Erdogan M., Gulcan H. O. , Aksakarl F., Oruklu N. , Bağrıaçık E. Ü. , ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.15, sa.1, ss.59-76, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1573406414666180524073241
  • Sayfa Sayıları: ss.59-76


Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.