Atıf İçin Kopyala
Kılıç B., Erdogan M., Gulcan H. O., Aksakarl F., Oruklu N., Bağrıaçık E. Ü., ...Daha Fazla
MEDICINAL CHEMISTRY, cilt.15, sa.1, ss.59-76, 2019 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
15
Sayı:
1
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Basım Tarihi:
2019
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Doi Numarası:
10.2174/1573406414666180524073241
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Dergi Adı:
MEDICINAL CHEMISTRY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.59-76
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Anahtar Kelimeler:
Alzheimer's disease, pyridazinone, acetylcholinesterase inhibitory activity, butyrylcholinesterase inhibitory activity, molecular docking, rational drug design, 1(2H)-PHTHALAZINONE DERIVATIVES, E2020 ARICEPT(R), ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, TOXICITY, BINDING, AGENTS, SITE
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Gazi Üniversitesi Adresli:
Evet
Özet
Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.