Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors

KILIÇ B. , Erdogan M., Gulcan H. O. , Aksakarl F., Oruklu N., BAĞRIAÇIK E. Ü. , ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.15, ss.59-76, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.