Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H-pyridazinon-2-yl]acetamides

Sukuroglu M. K., Ergun B., Unlu S., Sahin M., Kupeli E., Yesilada E., ...Daha Fazla

ARCHIVES OF PHARMACAL RESEARCH, cilt.28, sa.5, ss.509-517, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/bf02977751
  • Dergi Adı: ARCHIVES OF PHARMACAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.509-517
  • Anahtar Kelimeler: pyridazinone, pyrazole, analgesic, anti-inflammatory, writhing, carrageenan, AMIDE DERIVATIVES, PYRIDAZINONE DERIVATIVES, ANTINOCICEPTIVE ACTIVITY, DIFFERENTIAL INHIBITION, CLINICAL-SIGNIFICANCE, DRUGS
  • Gazi Üniversitesi Adresli: Evet

Özet

A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.