METAL OKSİT NANOPARTİKÜLLERİN GENOTOKSİK ETKİLERİ


Saygılı Y., ÜNAL F., YÜZBAŞIOĞLU D.

International journal of advances in engineering and pure sciences (Online), vol.33, no.3, pp.429-443, 2021 (Peer-Reviewed Journal) identifier

Abstract

Nanoparticles (NPs) (nanomaterials-NMs) are at the cutting edge of the speedily advancing area of nanotechnology. At least one dimension of these particles is in the range of 1-100 nm. Metal oxide NPs are the main members of nanomaterials. They have been applied in various fields such as medicine, cosmetics, paints, textiles, and food products. However, extensive use of metal oxide NPs leads to exposure of humans in various ways including inhalation, dermal, and oral routes. On the other hand, such an exposure raises concerns about their potential toxicity. The physicochemical properties of metal oxide NPs such as shape and size play an important role in their toxic effects. Studies about genotoxicity of metal oxide NPs on humans indicate that some metal oxide nanoparticles have genotoxic effects and they may be hazardous for humans. Therefore, in this study, genotoxic effects of some widely used metal oxide nanoparticles such as Al2O3, CeO2, CuO, Fe2O3, SiO2, TiO2, and ZnO were reviewed. Studies carried out using Ames (bacterial reverse mutation), chromosome aberration analysis, sister chromatid exchange, micronucleus, and comet assays were included. At the end, general mechanisms proposed for the genotoxic effects of metal oxide nanoparticles were presented.