The frequency of serum amyloid A1 alleles in Turkish and Azerbaijan populations

TAŞTAN H.

Biotechnology and Biotechnological Equipment, cilt.16, sa.2, ss.185-189, 2002 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 2002
  • Dergi Adı: Biotechnology and Biotechnological Equipment
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.185-189
  • Gazi Üniversitesi Adresli: Evet

Özet

Serum Amyloid A1 (SAA1), the predominant isotype of acute phase protein in plasma and the predominant precursor of fibrillar deposits in reactive amyloidosis, is encoded by a gene, for which six allelic variants have been described. This study determines the frequency of serum amyloid A1 alleles (SAA1.1, SAA1.5, SAA1.3) in Turkisk and Azerbaijan healthy subjects. Two hundred Turkish and sixty five Azerbaijan healthy individuals were studied by previously described PCR-RFLP methods. Our data revealed that the frequency of the 1.1 and 1.3 allele at the SAA1 locus in Turkish healthy population was significantly different when compared to Azerbaijan healthy population respectively (41.25 % versus 30.76 %, p<0.05; 15.75 % versus 28.46 %, p<0.05).