Nurses should be highly knowledgeable about and have a positive attitude toward pressure ulcer (PU) prevention. PURPOSE: This descriptive study was conducted among intensive care unit (ICU) nurses in 6 hospitals in Turkey to identify their PU prevention knowledge, attitudes, and perceptions of barriers to care. METHODS: The study was conducted between January 1, 2017, and April 30, 2017, using supervised self-reporting, among nurses working in the ICUs of 3 education and research hospitals, 2 university hospitals, and a private hospital in Ankara, Turkey. Three (3) data collection instruments were used: a participant sociodemographic data collection form, the Pressure Ulcer Prevention Knowledge Assessment Instrument (range 0-26, where higher scores indicate more knowledge), and the Attitude Towards Pressure Ulcer Prevention Instrument (range 13-52; a higher score implies a more positive attitude). Frequencies, t tests, analysis of variance, Pearson correlation analysis, and multiple regression analysis were used to analyze the data. RESULTS: Participants (N = 390) were mostly women (339; 86.9%) who had a bachelor's degree (283; 72.6%). The mean knowledge score was 11.54 +/- 2.91, and the mean attitude score was 42.96 +/- 4.06. The most commonly cited barriers to PU prevention were insufficient staff levels (85.6%) and pressure redistribution materials and equipment (82.6%). Regression analysis of attitude scores showed the following variables affected nurses' attitude toward PU prevention: self-sufficiency in PU risk assessment (beta = 0.28), willingness to learn more about preventing PU (beta = -0.15), gender (beta = -0.15), and knowledge score (beta = 0.14). CONCLUSION: ICU nurses were found to have a low levels of knowledge but positive attitudes toward PU prevention. Policies and procedures should be developed to increase ICU nurse knowledge levels and remove barriers to optimal PU prevention practices.