Discordances in HER2 status between primary gastric cancer and corresponding metastatic sites

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Gumusay O., Benekli M., EKİNCİ Ö., Baykara M., ÖZET A., Coskun U., ...Daha Fazla

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, cilt.45, sa.5, ss.416-421, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1093/jjco/hyv020
  • Dergi Adı: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.416-421
  • Anahtar Kelimeler: HER2, gastric cancer, discordance, IHC, SISH, HETEROGENEOUS AMPLIFICATION, CLINICAL-SIGNIFICANCE, GENE AMPLIFICATION, SCORING SYSTEM, BREAST-CANCER, HYBRIDIZATION, CARCINOMA, EXPRESSION, ERBB2, IMMUNOHISTOCHEMISTRY
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Determination of human epidermal growth factor receptor-2 status in advanced gastric cancer is important in clinical decision making. In the trastuzumab for GC trial, trastuzumab-based therapy demonstrated a significant overall survival benefit in patients with human epidermal growth factor receptor-2-positive advanced gastric cancer. Human epidermal growth factor receptor-2 discordance in gastric cancer primary and its metastases has been long debated. The aim of the study was to evaluate the rate of human epidermal growth factor receptor-2 discordance and its effect on treatment decisions in advanced gastric cancer.