Discordances in HER2 status between primary gastric cancer and corresponding metastatic sites
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, cilt.45, sa.5, ss.416-421, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 5
- Basım Tarihi: 2015
- Doi Numarası: 10.1093/jjco/hyv020
- Dergi Adı: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.416-421
- Anahtar Kelimeler: HER2, gastric cancer, discordance, IHC, SISH, HETEROGENEOUS AMPLIFICATION, CLINICAL-SIGNIFICANCE, GENE AMPLIFICATION, SCORING SYSTEM, BREAST-CANCER, HYBRIDIZATION, CARCINOMA, EXPRESSION, ERBB2, IMMUNOHISTOCHEMISTRY
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Objective: Determination of human epidermal growth factor receptor-2 status in advanced gastric cancer is important in clinical decision making. In the trastuzumab for GC trial, trastuzumab-based therapy demonstrated a significant overall survival benefit in patients with human epidermal growth factor receptor-2-positive advanced gastric cancer. Human epidermal growth factor receptor-2 discordance in gastric cancer primary and its metastases has been long debated. The aim of the study was to evaluate the rate of human epidermal growth factor receptor-2 discordance and its effect on treatment decisions in advanced gastric cancer.