Synthesis and antinociceptive activity of some 6-benzoyl-2(3H)-benzothiazolone derivatives


Cakir B., Dogruer S., ÜNLÜ S., Yesilada E., ŞAHİN M. G.

Gazi Universitesi Eczacilik Fakultesi Dergisi, vol.14, no.2, pp.103-109, 1997 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 1997
  • Journal Name: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.103-109

Abstract

Ten derivatives of 2(3H)-benzothiazolone carrying benzoyl moieties at the position 6 and methyl group at the position 3 have been synthesized and their structure elucidated by IR, 1H NMR spectral data and elemental analysis. Antinociceptive activity of the compounds has been investigated by modified Koster test in mice using aspirin as a reference. Compounds 1-3, 5-8 have been more potent than the reference.