Akademik Veri Yönetim Sistemi
MATERIALS TODAY CHEMISTRY, cilt.50, 2025 (SCI-Expanded, Scopus)
The rapid development in biomedicine presents both challenges and opportunities for macromolecules and polymers development. In this regard, click chemistry emerged as a powerful platform for constructing diverse and innovative materials tailored for biomedical applications. Light (photon)-driven click reactions proceed generally under near-ultraviolet (UV), mid-UV light or visible light are known as photoclick reactions. These reactions are non-invasive, have high spatiotemporal control, air tolerant, moisture tolerant with high selectivity and yields. The combination of click and photoclick reactions can link functionalized small molecules and macromolecules and produce cyclic, branched and network polymers. This review discusses introduction and mechanism of photoclick reactions, types of initiators used for the reactions, and modification needed for biopolymers to make them photocrosslinkable constituents. Moreover the preparation and uses of photocrosslinkable polymeric biomaterials (including hydrogels, scaffolds, and copolymers) including their uses with mesenchymal stem cells during the last five years (2019-2025) are described.