Akademik Veri Yönetim Sistemi
Journal of Gazi University Health Sciences Institute, 2022 (Hakemli Dergi)
Childhood asthma and obesity are serious and chronic public health
problems that require specific treatment. The prevalence of asthma in
obese individuals is higher than that of non-obese individuals. Despite
the belief that obesity is a major risk factor in the development of
asthma, the mechanisms and effects associated with obesity are yet to be
explained. It was considered that these two diseases are associated
with excess adipose tissue that predisposes patients to inflammation and
could contribute to the pathogenesis and severity of asthma. IL-17A and
IL-17F are cytokines with pro-inflammatory properties, and high levels
were observed in the serum of children with asthma and obesity. Also,
IL-36 is a proinflammatory cytokine that acts as a mediator between the
innate and adaptive immune systems to induce CXCL8 and IL-17
expressions. It could be suggested that these pro-inflammatory cytokines
could play a role in the association between the two conditions.
However, the activities of these cytokines are inhibited by
anti-inflammatory cytokines such as IL-36Ra. The present review aims to
explain the role of proinflammatory cytokines in adipose tissue and
airway structure, as well as the association between the Th17 cytokines
and the IL-36 cytokine family.