Development of melatonin loaded pectin nanoparticles for the treatment of inflammatory bowel disease: In vitro and in vivo studies

Yener, Serkan; Akbulut, KAZİME; Karakuş, RESUL; Erdogan, DENİZ; Acartürk, FÜSUN

doi:10.1016/j.jddst.2021.102861

Development of melatonin loaded pectin nanoparticles for the treatment of inflammatory bowel disease: In vitro and in vivo studies

Yener S., Akbulut K. G., Karakuş R., Erdogan D., Acartürk F.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.67, 2022 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 67
Basım Tarihi: 2022
Doi Numarası: 10.1016/j.jddst.2021.102861
Dergi Adı: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
Anahtar Kelimeler: Inflammatory bowel disease, Crohns disease, Melatonin, Pectin nanoparticle, ACID-INDUCED COLITIS, ULCERATIVE-COLITIS, NITRIC-OXIDE, CROHNS-DISEASE, DRUG-DELIVERY, PH, THERAPY, MUCOSA, MODEL, GLUTATHIONE
Gazi Üniversitesi Adresli: Evet

Özet

Inflammatory bowel disease (IBD) is a general term including long-term inflammatory disorders of all or some parts of the digestive system. Nanoparticles (NPs) can accumulate in the inflamed zone independently of the polymers' mucoadhesive character.