Is frailty a prognostic factor for critically ill elderly patients?


Kizilarslanoglu M. C., Civelek R., Kilic M. K., Sumer F., Varan H., Kara O., ...More

AGING CLINICAL AND EXPERIMENTAL RESEARCH, no.2, pp.247-255, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2017
  • Doi Number: 10.1007/s40520-016-0557-y
  • Journal Name: AGING CLINICAL AND EXPERIMENTAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.247-255
  • Keywords: Frailty, Elderly, Intensive care unit, APACHE II, SOFA score, INTENSIVE-CARE-UNIT, CRITICAL ILLNESS, MORTALITY, MULTICENTER, PREVALENCE, SURVIVORS, COHORT, LIFE, ICU
  • Gazi University Affiliated: Yes

Abstract

Aim The study aimed to investigate the effects of frailty on clinical outcomes of patients in an intensive care unit (ICU). Methods In this prospective study, 122 patients (59 frail, 37 pre-frail and 26 robust) were included. A frailty index (FI) derived from comprehensive geriatric assessment parameters was used for the evaluation. The FI score of <= 0.25 was considered as robust, 0.25-0.40 as pre-frail and >0.40 as frail. The prognostic effects of FI were investigated and FI and APACHE II and SOFA scores, the prognostic scores using in ICU, were compared. Results Median age of the patients was 71 years old and 50.8 % were male. ICU mortality rate and median length of stay (LOS) were 51.6 % and 8 days (min-max: 1-148), respectively. ICU mortality was higher (69.2, 56.8 and 40.7 %, respectively, p = 0.040) and median overall survival was lower in frail group compared to pre-frail and robust subjects (23, 31 and 140 days, p = 0.013, respectively). Long term mortality over 3 and 6 months in frail patients were 80.8 and 84.6 %, respectively and significantly higher than others. Multivariate analysis showed that LOS in ICU (HR 1.067, 95 % CI 1.021-1.114), SOFA score (HR 1.272, 95 % CI 1.096-1.476) and FI (HR 39.019, 95 % CI 1.235-1232.537) were the independent correlates for ICU mortality (p = 0.004, p = 0.002 and 0.038, respectively). There was a weak but statistically significant positive correlation between APACHE II and FI scores (r = 0.190, p = 0.036). Conclusions FI may be used as a predictor for the evaluation of elderly patients' clinical outcomes in ICUs.