Thalamocortical network interruption: A fresh view for migraine symptoms


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Bolay H. B.

Turkish journal of medical sciences, cilt.50, ss.1651-1654, 2020 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 50
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/sag-2005-21
  • Dergi Adı: Turkish journal of medical sciences
  • Sayfa Sayıları: ss.1651-1654

Özet

Abstract: Migraine is a multifaceted brain disorder where multisensory disturbances are associated with headache. Yet sensory symptoms are conventionally justified by dysfunctions confined to the cerebral cortex, a perspective through the complex interplay of thalamocortical network would provide the entire picture, more pertinent to the central sensory processing. It is important to consider thalamus as a hub that integrates multiple domains via extensive connections among anatomically and functionally separate cortical areas. Accordingly, cortical spreading depression (CSD), implicated in migraine pathophysiology can be seen as a tool to disconnect thalamocortical network by functionally eliminating cerebral cortex. Hence, including thalamic reticular nucleus and higher order thalamic nuclei, which conveys the information transthalamically among visual, somatosensory, language and motor cortical areas, would greatly improve our current understanding of migraine.

Key words: Migraine, headache, sensory discrimination, thalamocortical network, sensory integration, CSD