Effect of aluminum exposure on pteridine metabolism


BAYDAR T., ENGİN A. B., Aydin A., ŞAHİN G.

Biological Trace Element Research, cilt.106, sa.2, ss.153-164, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 106 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1385/bter:106:2:153
  • Dergi Adı: Biological Trace Element Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.153-164
  • Anahtar Kelimeler: Aluminum, Atomic absorption spectrometer, Biopterin, Dihydropteridine reductase, High-performance liquid chromatography, Neopterin, Pteridine
  • Gazi Üniversitesi Adresli: Evet

Özet

Occupational and environmental aluminum (Al) exposure cause serious health problems by interaction with biological systems. Al is one of the most documented metals because its cellular targets are unclear biochemical processes and membranes of organisms. The major aim of the present study was to investigate the alteration of serum and urine aluminum in occupational exposure and to observe whether the metal exposure could cause any changes in pteridine-pathway-related critical compounds such as urinary neopterin and biopterin and blood dihydropteridine reductase (DHPR). In this study, determination of the metal concentrations was carried out in Al-exposed workers (n=23) and healthy volunteers (n=18) by using atomic absorption spectrometer. DHPR enzyme activity and levels of neopterin and biopterin were detected by spectrophotometric and high-performance liquid chromatographic methods, respectively. It was found that occupational exposure to the metal led to a statistically significant increase in serum Al levels compared to the controls (p<0.05). At the same time, urinary neopterin and biopterin concentrations of the exposed group were higher than nonexposed subjects (both p<0.05). The correlations among Al levels and DHPR activity, magnesium concentration in serum and urine, working years, smoking status, and age were evaluated. © Copyright 2005 by Humana Press Inc. All rights of any nature, whatsoever, reserved.