Akademik Veri Yönetim Sistemi
ECZACILIKTA YENİLİKLER 5, Prof. Dr. Asuman BOZKIR Prof. Dr. Ceyda Tuba ŞENGEL TÜRK, Editör, Ankara Üniversitesi, Ankara, ss.711-725, 2025
The gut microbiota plays critical roles not only in the digestive system but also in the physiological regulation of several other systems, including immune system, nervous system, and skin. The increasingly recognized concept of the "gut–skin axis" refers to the bidirectional relationship between microbial balance in the gastrointestinal tract and skin health. Dysbiosis of gut microbiota may lead to disruptions in immune regulation, heightened inflammatory responses, and impaired epidermal barrier function, thereby contributing to the pathogenesis of skin diseases like acne vulgaris, atopic dermatitis, and psoriasis. This interaction is primarily mediated through four physiological mechanisms: modulation of immune system via the Treg–Th17 balance, production of microbial metabolites (SCFAs, indoles, kynurenines), maintenance of intestinal epithelial barrier integrity, and migration of immune cells to target tissues. As a therapeutic approach, probiotics, prebiotics, synbiotics, and postbiotics have demonstrated regulatory effects on both gut and skin health. These biological agents offer complementary and targeted strategies for the management of dermatological conditions by modulating systemic inflammation, balancing immune responses, and supporting epithelial barrier functions. In light of these findings, skin diseases should not be addressed solely with topical treatments but rather through comprehensive strategies that also consider systemic microbial balance.