Effects of melatonin in reducing the toxic enects of doxorubicin

Oz E., Ilhan M. N.

MOLECULAR AND CELLULAR BIOCHEMISTRY, vol.286, pp.11-15, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 286
  • Publication Date: 2006
  • Doi Number: 10.1007/s11010-005-9003-8
  • Journal Name: MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.11-15
  • Keywords: doxorubicin-induced toxicity, lipid peroxidation, melatonin, CONSTANT LIGHT EXPOSURE, HYPERLIPIDEMIC NEPHROPATHY, OXIDATIVE STRESS, LIPID-PEROXIDATION, RAT-BRAIN, ADRIAMYCIN, CARDIOTOXICITY, THERAPY, CANCER, DAMAGE
  • Gazi University Affiliated: Yes

Abstract

Anthracycline antibiotics, such as doxorubicin and daunorubicin, constitute a group of wide spectrum therapeutic agents. Application of these drugs in chemotherapy is limited because of their toxic effects. Melatonin, the main secretory product of pineal gland, was recently found as a free radical scavenger and antioxidant.