A cystic amelanotic melanoma metastasis to the brain: Case report

Creative Commons License

Cemil B., Emmez H., Oztanir N., Tokgoz N., Dogulu F.

Neurocirugia, vol.19, no.4, pp.365-367, 2008 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1016/s1130-1473(08)70225-2
  • Journal Name: Neurocirugia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.365-367
  • Keywords: Brain abscess, Brain metastases, Melanoma
  • Gazi University Affiliated: Yes


As far as we know, cyst formation in intracranial melanoma is rare, and only 15 cases of intracranial amelanotic melanoma have been reported until now. A yellowish mass was observed in the frontal lobe. The content of the cyst consisted of old hematoma, xanthochromic fluid and necrotic tissue, was evacuated and the cyst wall was totally resected. No abnormal pigmentation was noted in the cyst wall and surrounding brain tissue. The imaging features of metastatic melanomas are distinctive due to the presence of melanin and the propensity for hemorrhage. Both hemorrhage and melanin can produce T1-weighted hyperintensity and T2-weighted signal intensity loss.