EFFECTS OF EPIDERMAL GROWTH-FACTOR IN SERUM ZINC AND PLASMA PROSTAGLANDIN-E2 LEVELS OF MICE WITH PRESSURE SORES


GONUL B., SOYLEMEZOGLU T., YANICOGLU L., GUVENDIK G.

PROSTAGLANDINS, cilt.45, sa.2, ss.153-157, 1993 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Konu: 2
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/0090-6980(93)90030-b
  • Dergi Adı: PROSTAGLANDINS
  • Sayfa Sayıları: ss.153-157

Özet

This work was undertaken to study the effects of systemic application of EGF on the plasma PGE2 and serum zinc levels of mice with pressure sores. The pressure sores were made on the hind limb of the mice by bilateral sciatic nerve neurotomy. Mice were injected IP, 1 mug EGF daily for ten days, begining on the 21st day after operation. EGF administration increased the serum zinc and plasma PGE2 levels compared with controls. These results indicate that EGF can be effective on wound healing by elevating the serum zinc and plasma PGE2 concentrations together with other physiological roles in cellular events.