Effect of age on high-fat diet-induced hypertension

Erdos B., Kirichenko N., Whidden M., Basgut B., Woods M., Cudykier I., ...Daha Fazla

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, cilt.301, sa.1, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 301 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1152/ajpheart.01289.2010
  • Dergi Adı: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: aging, obesity, NADPH oxidase, circadian variation, baroreflex sensitivity, CATECHOLAMINE BIOSYNTHETIC-ENZYMES, BARORECEPTOR REFLEX SENSITIVITY, OBESITY-RELATED HYPERTENSION, SYMPATHETIC-NERVE ACTIVITY, BLOOD-PRESSURE REGULATION, CENTRAL ANGIOTENSIN-II, RAT ADRENAL-MEDULLA, TYROSINE-HYDROXYLASE, EMOTIONAL-STRESS, GENE-EXPRESSION
  • Gazi Üniversitesi Adresli: Hayır

Özet

Erdos B, Kirichenko N, Whidden M, Basgut B, Woods M, Cudykier I, Tawil R, Scarpace PJ, Tumer N. Effect of age on high-fat diet-induced hypertension. Am J Physiol Heart Circ Physiol 301: H164-H172, 2011. First published May 6, 2011; doi:10.1152/ajpheart.01289.2010.-Aging and obesity both have a significant impact on central blood pressure (BP) regulation, and previous studies indicated that changes in central redox signaling with age may affect high-fat (HF) diet-induced cardiovascular responses. Therefore, we investigated the effects of 60% HF feeding on BP regulation in young adult (5 mo) and old (26 mo) Fischer-344 X Brown-Norway rats. Radiotelemetric transmitters were implanted to measure BP, heart rate (HR), locomotor activity, and spontaneous baroreflex sensitivity. Expression and activity of NADPH oxidase and ANG II type 1 receptor were assessed in the hypothalamus and in the nucleus tractus solitarii. Old animals gained more weight on HF diet compared with young, whereas central NADPH oxidase expression and activity elevated similarly in the two age groups. After an initial hypotensive and tachycardic response during the first week of HF feeding, BP in young animals increased and became significantly elevated after 6 wk of HF feeding. In contrast, BP in old animals remained depressed. Nighttime HR and locomotor activity decreased in both young and old rats fed with HF diet, but these changes were more significant in young rats. As a result, amplitudes of circadian variation of BP, HR, and activity that were originally higher in young rats declined significantly and became similar in the two age groups. In conclusion, our experiments led to the surprising finding that HF diet has a more serious impact on cardiovascular regulation in young animals compared with old.