We aimed to evaluate hand grip strength and factors affecting this strength in patients with fibromyalgia. 21 patients with fibromyalgia and 18 healthy volunteers were included in this study. Patient and control groups were questioned about the disease-related symptoms. For global assessment of pain, fatigue and fibromyalgia; Visual Analog Scale (VAS; 0-100mm) was used. The localization, number and degree of the tender points were recorded. Dominant and non-dominant hand grip strengths were assessed by using vigorimeter. In the fibromyalgia group, mean grip strengths of dominant and non-dominant hand were 0.37 ± 0.11 bar and 0.36 ± 0.10, respectively. In the control group, the mean dominant hand grip strength was 0.61 ± 0.11 bar, and mean non-dominant hand grip strength was 0.56 ± 0.09 bar. The difference between the hand grip strength of the two groups was statistically significant (p < 0.001). No correlation was found between hand grip strength of fibromyalgia group and other clinical parameters (p > 0.05). Hand grip strength of fibromyalgia patients was lower than that of healthy volunteers. This finding was in accordance with muscle performance disorders that other studies have found.