Akademik Veri Yönetim Sistemi
Hacettepe University Journal of the Faculty of Pharmacy, cilt.45, sa.3, ss.245-254, 2025 (Scopus)
Electrospun nanofibers represent an excellent alternative to classical vaginal dosage forms due to flexibility, high loading capacity, high mucoadhesive strength and enhanced patient compliance. Eudragit®s, which are synthetic polymers composed of methacrylate monomers, are preferred for vaginal drug delivery. The aim of this study was to develop and evaluate Eudragit®-based nanofiber formulations for vaginal drug delivery. Nanofibers were fabricated using electrospinning. Eudragit® E100 was dissolved at varying concentrations in an an ethanol:dimethylformamide mixture (7:3, v/v). The polymer solutions were characterized in terms of surface tension, viscosity, and electrical conductivity. Thermal behavior of both the raw polymer and the nanofiber formulations was analyzed using Differential Scanning Calorimetry. Surface wettability was assessed by contact angle measurements using an optical tensiometer. The mechanical strength and mucoadhesive properties of the nanofibers were evaluated using a texture analyzer. The viscosity, surface tension and conductivity of the polymer solutions were found to be suitable for electrospinning. All formulations exhibited hydrophobic properties. Mechanical properties of formulations were increased with increasing polymer concentration. No statistically significant differences in mucoadhesion were observed among formulations. Based on comprehensive characterization, the E5 formulation exhibited the most favorable properties for vaginal use. It was seen that Eudragit-based formulations may be a potential platform for vaginal application.