The effects of iron on FGF23-mediated Ca-P metabolism in CKD patients


Deger S. M. , ERTEN Y. , PAŞAOĞLU Ö. T. , DERİCİ Ü. , ALTOK K. , Onec K., ...More

CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol.17, no.3, pp.416-423, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1007/s10157-012-0725-0
  • Title of Journal : CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Page Numbers: pp.416-423

Abstract

Fibroblast growth factor 23 (FGF23) is an important counterregulatory hormone for phosphate homeostasis. Since it has been reported that iron administration induces hypophosphatemic osteomalacia by triggering FGF23 synthesis, we hypothesized that iron administration might lead to a further increase in FGF23, resulting in alterations to Ca-P metabolism in a stage 5 CKD population.