The effects of iron on FGF23-mediated Ca-P metabolism in CKD patients


Deger S. M. , ERTEN Y. , PAŞAOĞLU Ö. T. , DERİCİ Ü. , ALTOK K. , Onec K., ...Daha Fazla

CLINICAL AND EXPERIMENTAL NEPHROLOGY, cilt.17, sa.3, ss.416-423, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s10157-012-0725-0
  • Dergi Adı: CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Sayfa Sayıları: ss.416-423

Özet

Fibroblast growth factor 23 (FGF23) is an important counterregulatory hormone for phosphate homeostasis. Since it has been reported that iron administration induces hypophosphatemic osteomalacia by triggering FGF23 synthesis, we hypothesized that iron administration might lead to a further increase in FGF23, resulting in alterations to Ca-P metabolism in a stage 5 CKD population.