Increased plasma levels of advanced oxidation protein products (AOPP) as a marker for oxidative stress in patients with active ulcerative colitis

ALAGÖZLÜ H., Gorgul A., Bilgihan A., Tuncer C., Unal S.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, vol.37, no.1, pp.80-85, 2013 (SCI-Expanded) identifier identifier identifier


Background and aims: After NADPH oxidase mediated radical formation, hypochloric acid (HOCl) is formed when Cl is used as a substrate by the myeloperoxidase enzyme. Myeloperoxidase is secreted from H2O2 activated leukocytes with polymorphic nuclei. The generation of HOCl also causes the formation of advanced oxidation protein products (AOPP) through damage to normal tissue and protein oxidation. AOPP has been identified as a marker of inflammation in many diseases. However, AOPP has not been investigated in ulcerative colitis.