Homocysteine thiolactonase activity in coronary atherosclerosis


Altinay A., Kısa Ü., Tulmac M., Özkan Y.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, vol.11, no.6, pp.634-638, 2020 (ESCI) identifier

Abstract

Aim: Discovery of paraoxonase natural substrate, homocysteine thiolactone, shed more light on the protective role of paraoxonase and toxicity of homocysteine. Since homocysteine thiolactone and paraoxon were hydrolyzed at different sites in the PON protein, the aim of this study was to investigate the Hcy-thiolactonase (HTase). This study was undertaken to ascertain whether low the Hcy-thiolactonase acitivity is associated with paraoxonase activity and to clarify its relation with ox-LDL and total plasma homocysteine levels in coronary artery diseasase.