Homocysteine thiolactonase activity in coronary atherosclerosis

Altinay A., Kısa Ü., Tulmac M., Özkan Y.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, cilt.11, sa.6, ss.634-638, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4328/acam.20168
  • Dergi Adı: ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.634-638
  • Gazi Üniversitesi Adresli: Evet

Özet

Aim: Discovery of paraoxonase natural substrate, homocysteine thiolactone, shed more light on the protective role of paraoxonase and toxicity of homocysteine. Since homocysteine thiolactone and paraoxon were hydrolyzed at different sites in the PON protein, the aim of this study was to investigate the Hcy-thiolactonase (HTase). This study was undertaken to ascertain whether low the Hcy-thiolactonase acitivity is associated with paraoxonase activity and to clarify its relation with ox-LDL and total plasma homocysteine levels in coronary artery diseasase.