Serum cytokine and growth factor levels in patients with endometriosis


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Kubatova A., ERDEM A., ERDEM M., Firatmutlu M., Korucuoglu U.

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, vol.38, no.4, pp.500-504, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.5114/ceji.2013.39768
  • Journal Name: CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.500-504
  • Keywords: endometriosis, serum marker, CA 125, TGF-beta 1, IL-6, IL-12, PERITONEAL-FLUID, INTERLEUKIN-6 LEVELS, WOMEN, CA-125, PREDICTION, MARKERS, IL-6
  • Gazi University Affiliated: Yes

Abstract

The aim of this prospective study is to define markers that can be used in the diagnosis and follow-up of patients with endometriosis by determining serum CA 125, transforming growth factor beta 1 (TGF-beta 1), interleukin 6 (IL-6), and IL-12 levels. The study group consisted of 14 patients diagnosed to have mild to moderate peritoneal endometriosis, 47 patients with ovarian endometrioma during laparoscopy and 12 healthy patients as a control group. Serum CA 125, TGF-beta 1, IL-6, and IL-12 levels were evaluated using ELISA kits. Serum CA 125 levels were significantly higher in the endometrioma group when compared to the control group (p < 0.001) and mild to moderate peritoneal endometriosis group (p <0.001). Mean serum TGF-beta 1 levels were signcantly higher in the endometrioma group when compared to the mild to moderate peritoneal endometriosis group (p < 0.001). In addition, serum TGF-beta 1 levels were found to be signcantly different with regard to the stage of the endometriosis. Serum IL-6 levels were significantly higher in the endometrioma group compared to the endometriosis group (p = 0.024) and control group (p = 0.05). Mean serum IL-12 levels were lower in patients with endometriosis. In conclusion; TGF-beta 1 and IL-6 measurements might be a promising alternative in adjunct to CA 125 for the non-invasive diagnosis of endometrioma. However CA 125, TGF-beta 1, IL-6 and IL-12 seem not to have the diagnostic value in the diagnosis of early stage endometriosis. Of all the serum markers studied, only TGF-beta 1 was found to be correlated with the stage of endometriosis.