Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

Sørensen, D.M.; Bostock, H.; Abrahao, A.; ALAAMEL, ABİR; Alaydin, H.C.; Ballegaard, M.; Boran, HÜRREM; CENGİZ, BÜLENT; de Carvalho, M.; Dunker, Ø.; Fuglsang-Frederiksen, A.; Graffe, C.C.; Jones, K.E.; Kallio, M.; Kalra, S.; Krarup, C.; Krøigård, T.; Liguori, R.; Lupescu, T.; Maitland, S.; Matamala, J.M.; Moldovan, M.; Moreno-Roco, J.; Nilsen, K.B.; Phung, L.; Santos, M.O.; Themistocleous, A.C.; Uysal, H.; Vacchiano, V.; Whittaker, R.G.; Zinman, L.; Tankisi, H.

doi:10.1016/j.clinph.2023.04.008

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

Atıf İçin Kopyala

Sørensen D., Bostock H., Abrahao A., ALAAMEL A., Alaydin H., Ballegaard M., ...Daha Fazla

Clinical Neurophysiology, cilt.151, ss.92-99, 2023 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 151
Basım Tarihi: 2023
Doi Numarası: 10.1016/j.clinph.2023.04.008
Dergi Adı: Clinical Neurophysiology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
Sayfa Sayıları: ss.92-99
Anahtar Kelimeler: CMAP Scan, Motor unit number estimation, MScanFit, MUNE, Repeatability
Gazi Üniversitesi Adresli: Evet

Özet

Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.