SERUM BIOMARKERS IN BREAST CANCER: INSIGHTS INTO NETRIN-4 AND ITS RECEPTORS
8. ULUSLARARASI SAĞLIK BİLİMLERİ VE YAŞAM KONGRESİ (IHSLC 2025), Burdur, Türkiye, 16 - 19 Nisan 2025, ss.68, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Burdur
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.68
- Gazi Üniversitesi Adresli: Evet
Özet
SERUM BIOMARKERS IN BREAST CANCER: INSIGHTS INTO NETRIN-4 AND ITS RECEPTORS
Fatma Şen*, Aymelek Gönenç*, Tuba Taşkan**, Taylan Turan* Osman Kurukahvecioğlu***
* Gazi University, Faculty of Pharmacy, Department of Biochemistry, Ankara, Turkey, fatma.sen1@gazi.edu.tr
* Gazi University, Faculty of Pharmacy, Department of Biochemistry, Ankara, Turkey,aymelek@gazi.edu.tr
** Afyonkarahisar Sağlık Bilimleri Üniversity, Faculty of Pharmacy, Department of Biochemistry, Afyon,Turkey,tuba.taskan@afsu.edu.tr
* Gazi University, Faculty of Pharmacy, Department of Biochemistry, Ankara, Turkey, taylanturan@gazi.edu.tr
*** Gazi University, Faculty of Medicine, Department of General Surgery, Ankara, Turkey,osmank@gazi.edu.tr
Background: Breast cancer is the most common type of cancer observed in women and accounts for 15% of cancer-related deaths among women. Netrin-4 has been shown in studies to play a role in axon guidance, stimulating and inhibiting angiogenesis, tumor formation, and the development of various cancers, including breast cancer. UNC5B and neogenin are receptors for Netrin-4. There are controversial results about expressions of Netrin-4 and its receptors in breast cancer.
Aim: The study aims to investigate whether there is a change in serum levels of measured parameters in patients compared to controls. Methods: In this study, Netrin-4, Neogenin, and UNC5B levels were measured by ELISA method using commercial kits in 50 breast cancer patients and 50 healthy controls. Results: Serum Netrin-4 and neogenin levels were found to be significantly lower in breast cancer patients compared to control groups p<0.01, p<0.01, respectively), whereas UNC5B levels were significantly higher (p<0.01).
Discussion and Conclusion: Some studies are showing decreased expression of Netrin-4 ve Neogenin and increased expression of UNC5B in breast cancer tissue. Our findings in serum samples are consistent with the studies performed in tissue for Netrin-4, Neogenin, and UNC5B in breast cancer.
This study is supported by the University of Gazi Scientific Research Projects (GUBAP) with the number TYL-2024-9335.
Anahtar Kelimeler:Netrin-4, breast cancer, neogenin, UNC5B