Synthesis, anti-inflammatory and analgesic activity screening of some new 4(3H)-quinazolinone derivatives


Yesilada A., Koyunoglu S., Saygili N., Kupeli E., Yesilada E., Bedir E., ...More

ARCHIV DER PHARMAZIE, vol.337, no.2, pp.96-104, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 337 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1002/ardp.200200752
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.96-104
  • Keywords: analgesic activity, anti-inflammatory activity, 4(3H)-quinazolinones, AGENTS, QUINAZOLINONES, INHIBITORS
  • Gazi University Affiliated: No

Abstract

4(3H)-Quinazolinone and pyrazole derivatives have been shown to have analgesic and anti-inflammatory properties. In this study, 14 new 3-methyl-4(3H)quinazolinone derivatives bearing 2-[1'-phenyl-3'-(substituted-phenyl)-2'-propenylidene]hydrazino or 2[5'-(substituted phenyl)-3'-phenyl-2'-pyrazolin-1'-yl] groups have been synthesized with the aim of obtaining new analgesic and anti-inflammatory leads. The structures were elucidated by means of UV, IR, H-1-NMR, C-13-NMR, mass spectroscopy, and elemental analysis data. The anti-inflammatory activities of the synthesized compounds were determined by carrageenan-induced hind paw edema test in mice. All the compounds showed statistically significant effects. For analgesic activity assessment, p-benzoquinone-induced writhing test was applied in mice. The results obtained were in accordance with the anti-inflammatory activity tests.