Parathormone, 1,25 dihydroxyvitamin D and prostaglandin E(2) correlation in children with idiopathic hypercalciuria


Hasanoglu A., Ercan Z., Buyan N., Memioglu N., Hasanoglu E.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol.56, no.3, pp.235-237, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 3
  • Publication Date: 1997
  • Doi Number: 10.1016/s0952-3278(97)90541-x
  • Title of Journal : PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
  • Page Numbers: pp.235-237

Abstract

As urinary prostaglandin excretion might be involved in idiopathic hypercalciuria, we studied the excretion of prostaglandin E(2) and calcium together with serum prostaglandin E(2), parathormone and 1,25 dihydroxyvitamin D in 20 patients and 11 controls Idiopathic hypercalciuric patients showed increased levels of urinary prostaglandin E(2)-like activity, which is correlated with calcium excretion. Although no change was observed in serum parathormone level in control and hypercalciuric patients, there was a positive correlation between serum 1,25 dihydroxyvitamin D and prostaglandin E(2)-like activity. These findings suggest that prostaglandin E(2) could play a role in the hypercalciuria syndrome, possibly by increasing 1,25 dihydroxyvitamin D synthesis.