Parathormone, 1,25 dihydroxyvitamin D and prostaglandin E(2) correlation in children with idiopathic hypercalciuria


Hasanoglu A., Ercan Z., Buyan N., Memioglu N., Hasanoglu E.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.56, sa.3, ss.235-237, 1997 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Konu: 3
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1016/s0952-3278(97)90541-x
  • Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
  • Sayfa Sayıları: ss.235-237

Özet

As urinary prostaglandin excretion might be involved in idiopathic hypercalciuria, we studied the excretion of prostaglandin E(2) and calcium together with serum prostaglandin E(2), parathormone and 1,25 dihydroxyvitamin D in 20 patients and 11 controls Idiopathic hypercalciuric patients showed increased levels of urinary prostaglandin E(2)-like activity, which is correlated with calcium excretion. Although no change was observed in serum parathormone level in control and hypercalciuric patients, there was a positive correlation between serum 1,25 dihydroxyvitamin D and prostaglandin E(2)-like activity. These findings suggest that prostaglandin E(2) could play a role in the hypercalciuria syndrome, possibly by increasing 1,25 dihydroxyvitamin D synthesis.