Objective: The aims of this study were the estimation and comparison of cardiovascular risk factors and the prevalence of metabolic syndrome (MetS) among pre-menopausal (pre-M) and post-menopausal (post-M) women. Material and Methods: This study was conducted on 664 (pre-M: 378, post-M: 286) women, aged between 30-64 years. Body weight and waist circumferences (WC) were measured in all participants. Additionally, body mass index (BMI) and waist/hip ratio (WHR) were calculated, and lipid profiles were determined. Results: The mean ages of pre-M women and post-M women were found as 42.1 +/- 4.50 and 56.2 +/- 4.19 years, respectively (p<0.001). Mean WC (p<0.001), WHR (p<0.001), systolic arterial pressure (SAP) (p<0.001), and diastolic arterial pressure (DAP) (p<0.001) levels were significantly higher in post-M women as compared to pre-M women. The mean fasting plasma glucose (FPG) (p=0.005), low-density lipoprotein cholesterol (LDL-C) (p=0.017), triglycerides (TG) (p=0.017), and total cholesterol/high density lipoprotein cholesterol (TC/HDL-C) (p=0.043) levels were significantly lower in pre-M women. However, TC level was significantly higher in post-M women (p<0.001). We found a significant increase in the prevalence of the MetS among the post-menopausal women depending upon the International Diabetes Federation (IDF) and The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Conclusion: Menopause is an important risk factor for metabolic syndrome. MetS was more prevalent among postmenopausal women compared to the premenopausal women depending upon both criteria.