Taurine and calcium interaction in protection of myocardium exposed to ischemic reperfusion injury


Oz E., Erbas D., Gelir E., Aricioglu A.

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, vol.33, no.2, pp.137-141, 1999 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 1999
  • Doi Number: 10.1016/s0306-3623(98)00284-5
  • Title of Journal : GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
  • Page Numbers: pp.137-141

Abstract

We aimed to investigate the cardio-protective role of taurine with low calcium level against reperfusion damage by adding taurine to extracellular fluid. Guinea-pig hearts were mounted on Langendorf perfusion apparatus and different compositions of perfusion solutions were prepared for each experimental group. After 20 min of normothermic ischemia the hearts were reperfused. Pre-ischemic, post-ischemic and post-reperfusion percentage changes of heart rate and contractile force were compared. Post-reperfusion tissue weight, malondialdehyde (MDA) and prostaglandin E-like activity (PGE-like activity) were assessed. Taurine-added low-calcium perfusion solution significantly decreased the postischemic myocardial injury. Published by Elsevier Science Inc.