Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzothiazolon-3-yl)propanamide derivatives


Onkol T., Yildirim E., Erol K., Ito S., Sahin M.

ARCHIV DER PHARMAZIE, vol.337, no.9, pp.475-481, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 337 Issue: 9
  • Publication Date: 2004
  • Doi Number: 10.1002/ardp.200300863
  • Title of Journal : ARCHIV DER PHARMAZIE
  • Page Numbers: pp.475-481

Abstract

Ten new (5-chloro-2(3H)-benzothiazolon-3-yl) propanamide derivatives have been synthesized. The compounds were tested for antinociceptive activity by tail clip, tail flick, hot plate and writhing test by using aspirin and dipyrone as standards. Among these compounds, 1-[3-(5-chloro-2(3H)-benzothiazolon-3-yl)propanoyl]-4-(4-chlorophenyl)piperazine (11e) has been found to be significantly more active than the other compounds synthesized as well as the standards in all tests.