Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzothiazolon-3-yl)propanamide derivatives

Onkol T., Yildirim E., Erol K., Ito S., Sahin M.

ARCHIV DER PHARMAZIE, cilt.337, sa.9, ss.475-481, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 337 Sayı: 9
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1002/ardp.200300863
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.475-481
  • Gazi Üniversitesi Adresli: Hayır

Özet

Ten new (5-chloro-2(3H)-benzothiazolon-3-yl) propanamide derivatives have been synthesized. The compounds were tested for antinociceptive activity by tail clip, tail flick, hot plate and writhing test by using aspirin and dipyrone as standards. Among these compounds, 1-[3-(5-chloro-2(3H)-benzothiazolon-3-yl)propanoyl]-4-(4-chlorophenyl)piperazine (11e) has been found to be significantly more active than the other compounds synthesized as well as the standards in all tests.