DHA, Cortisol and Thyroid Hormones in AntiAging Therapy


Karakoc A.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.28, no.6, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2008
  • Journal Name: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Gazi University Affiliated: No

Abstract

Endocrine system has an important role in the apperance of changes that seen during aging. Peripheral conversion of thyroxine (T4) to triiodothyronin (T3) decrases gradually with aging. The serum triiodothyronin concentration decreses but remain in normal ranges. it is not clear that whether healthy old people benefit from T3 replacement therapy. Adrenal glands are another hormonal system that change during aging (adrenopause). During aging while dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) levels decrease, cortisol levels increase by 20-50%. In the antiaging therapy glucocorticoids don't have any role. Several randomized controlled trials showed efficacy of oral DHEA treatment. Meanwhile, it is still too early to advise DHEA treatment for either preventing or delaying the aging.