Objective: Prostate fusion biopsy could be performed either transrectal or transperineal route. Interestingly, the risk of infective complications after transperineal approach does not seem fewer than transrectal approach. Even when transperineal approach is chosen surgeons may have to deal with fecal contents during the biopsy procedure. We have developed a simple modification to minimize perineal contamination during transperineal prostate fusion biopsy. In this study, the results of patients who underwent transperineal fusion biopsy by using our novel technique were presented.