Impact of chlorhexidine mouth rinse use on postextraction infection via nitric oxide pathway

ÖZMERİÇ KURTULUŞ N., Mollaoglu N., Elgun S., DEVRİM E.

INFLAMMATION RESEARCH, vol.59, no.6, pp.437-441, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1007/s00011-009-0115-6
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.437-441
  • Keywords: Nitric oxide, Arginase, Chlorhexidine, Saliva, Gingiva, PERIODONTAL-DISEASE, GINGIVAL TISSUE, SYNTHASE, INHIBITION, EXPRESSION
  • Gazi University Affiliated: Yes


Nitric oxide (NO) has been linked to inflammatory reactions, tissue destruction, host defense, and wound healing in oral diseases. It is known that arginase enzyme controls the synthesis of NO through arginine depletion. This study evaluated the arginase-NO pathway alteration in response to tissue injury after dental extraction surgery and the effect of postoperative use of 0.2% chlorhexidine gluconate rinse (CHX).