Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM)

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Albayrak G., KONAÇ E., Dere U. A. , Emmez H.

TURKISH NEUROSURGERY, vol.31, no.2, pp.233-237, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.5137/1019-5149.jtn.29176-20.3
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.233-237
  • Keywords: Glioblastoma, Cancer cell, Metabolism, Metformin, Dichloroacetate, Memantine

Abstract

AIM: To investigate the effects of metformin, dichloroacetate (DCA), and memantine on T98G and U87-MG human glioblastoma (GBM) cells to target tumor cell metabolism in a multi-directional manner.