Peroxynitrite: A putative cytotoxin
PHARMACOLOGY & TOXICOLOGY, cilt.82, sa.3, ss.113-117, 1998 (SCI-Expanded)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 82 Sayı: 3
- Basım Tarihi: 1998
- Doi Numarası: 10.1111/j.1600-0773.1998.tb01408.x
- Dergi Adı: PHARMACOLOGY & TOXICOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.113-117
- Gazi Üniversitesi Adresli: Hayır
Özet
In recent years it has become apparent that peroxynitrite, which is one of the toxic metabolites originating from the reaction of nitric oxide and superoxide presents a number of pathologic states in which free radicals are thought to be involved. Peroxynitrite is capable of oxidizing a wide variety of biomolecules including plasma, proteins, lipids, carbohydrates and nucleic acids. Peroxynitrite is involved in the hydroxylation of aromatic compounds and acts as a nitrating agent. It modifies free or protein-associated tyrosine residues to give nitrotyrosines, leaving a marker detectable in vivo. Peroxynitrite has been implicated in the pathophysiology of a variety of diseases including inflammation, atherosclerosis, arthritis, endotoxemia, ischaemia-reperfusion injury, or acute respiratory distress syndrome. Development of specific per oxynitrite scavengers may provide new approaches for the effective treatment of these disease states.