Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function

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Villarroel J. P. P., Figueredo R., Guan Y., Tomaiuolo M., Karamercan M. A., Welsh J., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.184, sa.1, ss.422-429, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 184 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jss.2013.05.097
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.422-429
  • Anahtar Kelimeler: High-resolution respirometry, Mitochondrial respiratory capacity, Platelet activation, Systemic organ, Resuscitation, FRESH WHOLE-BLOOD, TRAUMA PATIENTS, TRANSFUSED PLATELETS, CARDIAC-SURGERY, IMPACT, COAGULOPATHY, ACTIVATION, LESION, REDUCTION, MORTALITY
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Hemorrhagic shock is a leading cause of death following severe trauma, and platelet transfusions are frequently necessary to achieve hemostasis. Platelets, however, require special storage conditions, and storage time has been associated with loss of platelet quality. We hypothesized that standard storage conditions have a deleterious effect on platelet mitochondrial function and platelet activation.