Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function

Villarroel, Jose; Figueredo, Ronald; Guan, Yuxia; Tomaiuolo, Maurizio; Karamercan, Mehmet; Welsh, John; Selak, Mary; Becker, Lance; Sims, Carrie

doi:10.1016/j.jss.2013.05.097

Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function

Atıf İçin Kopyala

Villarroel J. P. P. , Figueredo R., Guan Y., Tomaiuolo M., Karamercan M. A. , Welsh J., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.184, ss.422-429, 2013 (SCI İndekslerine Giren Dergi)

Cilt numarası: 184 Konu: 1
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.jss.2013.05.097
Dergi Adı: JOURNAL OF SURGICAL RESEARCH
Sayfa Sayıları: ss.422-429

Özet

Background: Hemorrhagic shock is a leading cause of death following severe trauma, and platelet transfusions are frequently necessary to achieve hemostasis. Platelets, however, require special storage conditions, and storage time has been associated with loss of platelet quality. We hypothesized that standard storage conditions have a deleterious effect on platelet mitochondrial function and platelet activation.