Biological activities of lignans from Taxus baccata L. growing in Turkey

Kucukboyaci N., Sener B.

JOURNAL OF MEDICINAL PLANTS RESEARCH, cilt.4, sa.12, ss.1136-1140, 2010 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 12
  • Basım Tarihi: 2010
  • Dergi Adı: JOURNAL OF MEDICINAL PLANTS RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.1136-1140
  • Anahtar Kelimeler: Taxus baccata, taxaceae, lignans, anti-inflammatory, antinociceptive, anti-ulcerogenic, antimicrobial, cytotoxicity, enzyme inhibitory, antioxidant, SPECTROSCOPIC CHARACTERISTICS, HEARTWOOD, CONSTITUENTS, TOXICITY
  • Gazi Üniversitesi Adresli: Evet

Özet

Phytochemical investigation of Taxus baccata L. (Taxaceae) by successive chromatographic methods resulted in the isolation of the lignans; lariciresinol (1), taxiresinol (2), 3'-demethylisolariciresinol-9'-hydroxyisopropylether (3), isolariciresinol (4) and 3-demethylisolariciresinol (5) as well as taxoids. Compounds 1 - 5 were evaluated for their several biological activities such as anti-inflammatory, antinociceptive, anti-ulcerogenic, antimicrobial, cytotoxic, and antioxidant as well as acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase (LOX) inhibitory activities. In this review, the diverse biological activity profiles of lignan derivative compounds (1 - 5) obtained from T. baccata growing in Turkey will be discussed.