Biological activities of lignans from Taxus baccata L. growing in Turkey


Kucukboyaci N., Sener B.

JOURNAL OF MEDICINAL PLANTS RESEARCH, vol.4, no.12, pp.1136-1140, 2010 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 12
  • Publication Date: 2010
  • Title of Journal : JOURNAL OF MEDICINAL PLANTS RESEARCH
  • Page Numbers: pp.1136-1140

Abstract

Phytochemical investigation of Taxus baccata L. (Taxaceae) by successive chromatographic methods resulted in the isolation of the lignans; lariciresinol (1), taxiresinol (2), 3'-demethylisolariciresinol-9'-hydroxyisopropylether (3), isolariciresinol (4) and 3-demethylisolariciresinol (5) as well as taxoids. Compounds 1 - 5 were evaluated for their several biological activities such as anti-inflammatory, antinociceptive, anti-ulcerogenic, antimicrobial, cytotoxic, and antioxidant as well as acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase (LOX) inhibitory activities. In this review, the diverse biological activity profiles of lignan derivative compounds (1 - 5) obtained from T. baccata growing in Turkey will be discussed.