Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site


Ben Hadda T., Talhi O., Silva A. S. M. , ŞENOL DENİZ F. S. , ERDOĞAN ORHAN İ. , Rauf A., ...Daha Fazla

MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.18, sa.8, ss.711-716, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1389557517666170713114039
  • Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.711-716

Özet

Background: Cholinesterase family consists of two sister enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which hydrolyze acetylcholine. Since deficit of acetylcholine has been evidenced in patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drugs for the treatment of AD.