Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site


Ben Hadda T., Talhi O., Silva A. S. M. , ŞENOL DENİZ F. S. , ERDOĞAN ORHAN İ. , Rauf A., ...More

MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol.18, no.8, pp.711-716, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 18 Issue: 8
  • Publication Date: 2018
  • Doi Number: 10.2174/1389557517666170713114039
  • Title of Journal : MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Page Numbers: pp.711-716

Abstract

Background: Cholinesterase family consists of two sister enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which hydrolyze acetylcholine. Since deficit of acetylcholine has been evidenced in patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drugs for the treatment of AD.