Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

Ben Hadda, Taibi; Talhi, Oualid; Silva, Artur; ŞENOL DENİZ, FATMA; ERDOĞAN ORHAN, İLKAY; Rauf, Abdur; Mabkhot, Yahia; Bachari, Khaldoun; Warad, Ismail; Farghaly, Thoraya; Althagafi, Ismail; Mubarak, Mohammad

doi:10.2174/1389557517666170713114039

Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

Atıf İçin Kopyala

Ben Hadda T., Talhi O., Silva A. S. M. , ŞENOL DENİZ F. S. , ERDOĞAN ORHAN İ. , Rauf A., ...Daha Fazla

MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.18, sa.8, ss.711-716, 2018 (SCI İndekslerine Giren Dergi)

Cilt numarası: 18 Konu: 8
Basım Tarihi: 2018
Doi Numarası: 10.2174/1389557517666170713114039
Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
Sayfa Sayıları: ss.711-716

Özet

Background: Cholinesterase family consists of two sister enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which hydrolyze acetylcholine. Since deficit of acetylcholine has been evidenced in patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drugs for the treatment of AD.