Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

Ben Hadda T., Talhi O., Silva A. S. M., ŞENOL DENİZ F. S., ERDOĞAN ORHAN İ., Rauf A., ...Daha Fazla

MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.18, sa.8, ss.711-716, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 18 Sayı: 8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1389557517666170713114039
  • Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.711-716
  • Anahtar Kelimeler: Alzheimer's disease (AD), cholinesterases, crystalline structure, Petra/Osiris/Molinspiration (POM) analyses, spiro heterocycles, pharmacophore, BIOACTIVITY, ANTIBACTERIAL
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Cholinesterase family consists of two sister enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which hydrolyze acetylcholine. Since deficit of acetylcholine has been evidenced in patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drugs for the treatment of AD.