Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

Ben Hadda, Taibi; Talhi, Oualid; Silva, Artur; ŞENOL DENİZ, FATMA; ERDOĞAN ORHAN, İLKAY; Rauf, Abdur; Mabkhot, Yahia; Bachari, Khaldoun; Warad, Ismail; Farghaly, Thoraya; Althagafi, Ismail; Mubarak, Mohammad

doi:10.2174/1389557517666170713114039

Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

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Ben Hadda T., Talhi O., Silva A. S. M. , ŞENOL DENİZ F. S. , ERDOĞAN ORHAN İ. , Rauf A., ...More

MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol.18, no.8, pp.711-716, 2018 (Journal Indexed in SCI)

Publication Type: Article / Review
Volume: 18 Issue: 8
Publication Date: 2018
Doi Number: 10.2174/1389557517666170713114039
Title of Journal : MINI-REVIEWS IN MEDICINAL CHEMISTRY
Page Numbers: pp.711-716

Abstract

Background: Cholinesterase family consists of two sister enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which hydrolyze acetylcholine. Since deficit of acetylcholine has been evidenced in patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drugs for the treatment of AD.