The multiple functions and mechanisms of osteopontin


Icer M. A. , Gezmen Karadağ M.

CLINICAL BIOCHEMISTRY, vol.59, pp.17-24, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 59
  • Publication Date: 2018
  • Doi Number: 10.1016/j.clinbiochem.2018.07.003
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.17-24
  • Keywords: Osteopontin, Biomarker, Medicinal biochemistry, Obesity, Cancer, BONE-MATRIX PROTEINS, ADIPOSE-TISSUE, UP-REGULATION, TRANSCRIPTION FACTOR, CELL-SURVIVAL, MICE LACKING, HIGH GLUCOSE, DIABETIC-NEPHROPATHY, ENHANCED EXPRESSION, INSULIN-RESISTANCE
  • Gazi University Affiliated: Yes

Abstract

Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important functions on cardiovascular diseases, cancer, diabetes and kidney stone diseases and in the process of inflammation, biomineralization, cell viability and wound healing. Osteopontin acts on organisms by playing a key role in secretion levels of interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-3 (IL-3), interferon-gamma (IFN-gamma), integrin alpha vB3, nuclear factor kappa B (NF-kappa B), macrophage and T cells, regulating the osteoclast function and affecting CD44 receptors. The aim of the present review is to address majority of different functions of OPN protein which are known, suspected or suggested through the data obtained about this protein yet.