Iron homeostasis is altered in response to hypoxia and hypothermic preconditioning in brain glial cells

Aral L. A., Ergün M. A., Engin A. B., Börcek A. Ö., Belen H. B.

Turkish journal of medical sciences, cilt.50, sa.8, ss.2005-2016, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 8
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/sag-2003-41
  • Dergi Adı: Turkish journal of medical sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.2005-2016
  • Anahtar Kelimeler: Hypoxic brain injury, glia, iron, ferritin, hypothermia, preconditioning, PERIVENTRICULAR WHITE-MATTER, AMEBOID MICROGLIAL CELLS, THERAPEUTIC HYPOTHERMIA, INFLAMMATORY RESPONSE, METABOLIC ADAPTATION, REGULATORY PROTEINS, LIGHT-CHAIN, INJURY, MECHANISMS, TOLERANCE
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: Altered iron metabolism is one of the pathophysiological mechanisms occurring during hypoxic injuries in the central nervous system. Proper homeostasis of cellular iron is regulated by iron import, storage, and export proteins that prevent excess iron overload or iron starvation in cells. Therapeutic hypothermia is an approved treatment for hypoxic ischemia in newborns, but the underlying molecular mechanism is still unknown. We studied the effects of hypoxia, preceded with preconditioning, on the iron homeostasis of glial cells, known as a major actor in the inflammatory process during perinatal brain injury.