Iron homeostasis is altered in response to hypoxia and hypothermic preconditioning in brain glial cells


Aral L. A. , Ergün M. A. , Engin A. B. , Börcek A. Ö. , Belen H. B.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.50, no.8, pp.2005-2016, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-2003-41
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.2005-2016

Abstract

Background/aim: Altered iron metabolism is one of the pathophysiological mechanisms occurring during hypoxic injuries in the central nervous system. Proper homeostasis of cellular iron is regulated by iron import, storage, and export proteins that prevent excess iron overload or iron starvation in cells. Therapeutic hypothermia is an approved treatment for hypoxic ischemia in newborns, but the underlying molecular mechanism is still unknown. We studied the effects of hypoxia, preceded with preconditioning, on the iron homeostasis of glial cells, known as a major actor in the inflammatory process during perinatal brain injury.