Akademik Veri Yönetim Sistemi
International Conference of Biochemists and Molecular Biologists in Bosnia and Herzegovina - ABMBBIH, Sarajevo, Bosna-Hersek, 27 - 30 Mayıs 2023, ss.17
Systemic inflammation is thought to influence neurogenic inflammation in many neurological diseases.
Neurogenic inflammation is one of the most important components of migraine pathophysiology.
Pentraxin-3 is a novel acute-phase protein recognized as an inflammatory response of the body. In this
study, it was aimed to investigate the levels of pentraxin-3 in patients with migraine.
45 patients with migraine and 39 healthy controls were included in the study. Peripheric blood samples
were taken from patients and control group. After the samples were centrifuged and the levels of
pentraxin-3 were measured from the acquired serums by enzyme-linked immunosorbent assay
(ELISA). Statistical Package for the Social Sciences (SPSS, version 18.0, Chicago, IL, USA) statistics
program was used for evaluating the data. Mann-Whitney U test was performed on non-normally
distributed data and was reflected as median (minimum value-maximum value). p≤ 0.05 was accepted
as statistically significant between groups. 26 patients were male and 19 patients were female. Patient’s
average of age was 49.36±11.92 years. In healthy control group, 21 person male and 18 person were
female. The average age of healthy control was 53.3±9.93 years. In the comparison between migraine
patients and the control group, serum Pentraxin-3 levels were found to be statistically significantly
higher in migraine patients (11.10(2.09-15.95)) ng/mL) than in the control group (9.65 (0.97-12.34))
ng/mL). Pentraxin-3 plays an important role in activation of innate immunity and in the regulation of
inflammatory reactions. Results from this study suggest that Pentraxin-3 level may be a novel
biochemical marker for migraine. Further studies are needed to confirm the pathophysiological role of
pentraxin-3 in migraine