Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat

Cakmak, G.; Irkorucu, O.; Ucan, B.; Emre, A.; Bahadir, B.; Demirtas, CANAN; Tascilar, O.; Karakaya, K.; Acikgoz, S.; Kertis, G.; Ankarali, H.; Pasaoglu, HATİCE; Comert, M.

doi:10.1007/s11605-009-0951-2

Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat

Atıf İçin Kopyala

Cakmak G. K. , Irkorucu O., Ucan B. H. , Emre A. U. , Bahadir B., Demirtas C. , ...Daha Fazla

JOURNAL OF GASTROINTESTINAL SURGERY, cilt.13, sa.9, ss.1707-1716, 2009 (SCI İndekslerine Giren Dergi)

Cilt numarası: 13 Konu: 9
Basım Tarihi: 2009
Doi Numarası: 10.1007/s11605-009-0951-2
Dergi Adı: JOURNAL OF GASTROINTESTINAL SURGERY
Sayfa Sayıları: ss.1707-1716

Özet

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis.