Objective: To evaluate the patients followed and treated with a diagnosis of gestational trophoblastic disease in our clinic retrospectively. Design: The files of the patients followed and treated in our clinic between 1996 and 2010 with a diagnosis of gestational trophoblastic disease were examined. Setting: Yuzuncu YIl University, Faculty of Medicine, Department of Obstetrics and Gynecology, Van. Patients: The 147 patients with satisfactory information in their files within 173 patients treated and followed in our clinic between 1996 and 2010 with a diagnosis of gestational trophoblastic disease. Interventions: No intervention to the patients. Main outcome measures: Demographic and obstetric parameters, blood group,obstetric history in the previous pregnancy, contraceptive method, gestational week and complaints on admission, hystological type, stage, treatment and complications of gestational trophoblastic disease and presence of associated clinical problems. Results: In our clinic, 18.324 deliveries occured and 173 cases had a diagnosis of gestational trophoblastic disease between 1996 and 2010. Out of 147 patients, 72 (49%), 61 (41.5%), 3 (2%), 7 (4.8%) and 1 (0.7%) had diagnoses of complete mole, partial mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor, respectively. In 3 patients (2%), subtype could not be determined. Mean age was 31.45 ± 10.29 years and the most common complaint was vaginal bleeding (77.6%). As the primary therapy, suction curettage with oxytocin infusion or hysterectomy was appplied to 140 and 7 patients, respectively. A single agent chemotherapy was performed to 26 patients while a multiagent chemotherapy was given to 6 patients. All patients were followed up by serial serum β-hCG measurements. Conclusions: The incidence of gestational trophoblastic disease in our clinic was calculated as 8.1 per 1000 deliveries and socio-economic and educational status of majority of the patients were low. Lowering the high birth rate in our region may contribute to decrease of disease incidence.