Studies on the formulation optimization and controlled ionic gelation of chitosan nanoparticles using TPP-HP-beta-CD inclusion complex
ISTANBUL JOURNAL OF PHARMACY, cilt.50, sa.1, ss.54-59, 2020 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.26650/istanbuljpharm.2019.0015
- Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.54-59
- Anahtar Kelimeler: Chitosan nanoparticles, controlled ionic gelation, cyclodextrins, POLYMERIC NANOPARTICLES
- Gazi Üniversitesi Adresli: Evet
Özet
Background and Aims: Ionic gelation strategy is the most common method used for the preparation of chitosan nanoparticles to obtain controlled drug delivery. Although it is a convenient and easy method, it is highly related with particle aggregation, high polidispersity index and insufficient physical/chemical stability. The aim of this study was the development of chitosan nanoparticles using tripolyphosphate-hydroxy propyl beta-cyclodextrin or tripolyphosphate-sulfobutyl ether beta-cyclodextrin inclusion complex as an alternative to TPP, and hence to increase physical stability, reduce polidispersity index and develop a stable nanocarrier for drug delivery purposes.