Studies on the formulation optimization and controlled ionic gelation of chitosan nanoparticles using TPP-HP-beta-CD inclusion complex

Agardan M.

ISTANBUL JOURNAL OF PHARMACY, cilt.50, sa.1, ss.54-59, 2020 (ESCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.26650/istanbuljpharm.2019.0015
  • Sayfa Sayıları: ss.54-59


Background and Aims: Ionic gelation strategy is the most common method used for the preparation of chitosan nanoparticles to obtain controlled drug delivery. Although it is a convenient and easy method, it is highly related with particle aggregation, high polidispersity index and insufficient physical/chemical stability. The aim of this study was the development of chitosan nanoparticles using tripolyphosphate-hydroxy propyl beta-cyclodextrin or tripolyphosphate-sulfobutyl ether beta-cyclodextrin inclusion complex as an alternative to TPP, and hence to increase physical stability, reduce polidispersity index and develop a stable nanocarrier for drug delivery purposes.